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I have the same question (0)Assuming you're talking about Windows Server 2008 R2:
Main disadvantages would be that standard only supports 4 x64 sockets (/cpu's) instead of 8 and 32GB max. memory instead of 2TB.
Further information can be found at [url]download.microsoft.com/.../WS%20Brand%20Pages%20-%20Editions%20Comparison%20Guide.pdf[/url]