RE: Setting users passwords on GP2018
                     
                    
                      
                        It is possible, yes.
Specifically, the encryption of GP user passwords is setup per the server name in the DSN, so if they are different on two machines, such as your server and PC, it can cause this to not work.
Again, to verify this, reset the user's password in Dynamics GP on the server and verify they can login. If they can, have them then attempt to login on the PC.
If they cannot login to the PC, but can login on the server, reset their password in Dynamics GP on the PC, then verify they can now login to GP on this PC. If they can, have them try logging into GP back on the server again.
If they now cannot login to GP on the server, then it's most likely what you're running into.