Hi Patrick,
You could create a custom entity for the domains and then a workflow to update the contacts with those addresses not to receive email in Dynamics 365 for Marketing but there is no OOB functionality which will support this ask. Or you could do an upsert to update all of the contacts with those addresses to set the flag as well. You could also do this manually or build it into segmentation to use as a suppression segment.
Thanks,
Megan
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