Hi Preetam,
Yes, it is possible.
Go to Settings > Document Management > SharePoint Sites, new a site.


Then go to Document Management Settings, enable the SharePoint Site URL, next to set the site for entities.


Go to entity form, in the Files or Documents tab, click Add Location.

Select the new SharePoint Site in the Parent Site. Save.

Then we can upload the files to the new SharePoint Documents Location of the new site.
