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This weekend I set up a new Small Business Server 2008 for a client and included CRM 4.0 Workgroup Edition. I was able to access CRM fine using the web client from the server but when I attempted to access it from the client workstations, it wouldn’t connect. Short story shorter, the issue turned out to be the Windows Firewall on the server. You have to open up the firewall for the CRM port (5555 by default).