Hey Dynamics Community

We have a Problem with our CRM 2011 (like we have every Month, I wish we could just Upgrade...).

If some of our Users try to Open the CRM they get the Message "CRM failed to load".

In October the Update "KB4011089" created the same Problem, back then it was fixed with the Reg "EnableRoamingFolderHomepages"=dword:00000002 but I checked that and that Key is set.

Is there any other known issue right now that can cause that Problem? I have no clue where to look, so I am grateful for every help I can get.